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A historic skeleton with osteomyelosclerosis.

C Kramar1, C A Baud, R Lagier

  • 1Department of Anthropology, University of Geneva, Switzerland.

Archives of Pathology & Laboratory Medicine
|May 1, 1990
PubMed
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Osteomyelosclerosis, an advanced myelofibrosis stage, was diagnosed in a 17th-18th century skeleton. Findings included new microspongiosa, thickened trabeculae, and subperiosteal bone thickening.

Area of Science:

  • Paleopathology
  • Hematology
  • Skeletal Biology

Background:

  • Myeloproliferative neoplasms represent a group of disorders characterized by the overproduction of one or more hematopoietic cell lines.
  • Myelofibrosis is an advanced stage of myeloproliferative neoplasm, often associated with bone marrow fibrosis.
  • Osteomyelosclerosis is a rare manifestation of myelofibrosis, characterized by bone sclerosis.

Observation:

  • A skeletal case from the 17th or 18th century was examined.
  • The skeleton belonged to an adult male.
  • Skeletal analysis focused on bone morphology and structure.

Findings:

  • The diagnosis of osteomyelosclerosis was established based on specific skeletal changes.
  • Key diagnostic features included the presence of newly formed microspongiosa.

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  • Thickening of preexisting trabeculae and subperiosteal thickening of cortical bone were also observed.

    • Implications:

    • This case provides evidence of myelofibrosis in historical populations.
    • The findings contribute to understanding the paleopathology of myeloproliferative disorders.
    • Skeletal analysis offers unique insights into the manifestation of hematological diseases in the past.