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Lipophilicity of some substituted morpholine derivatives synthesized as potential antinociceptive agents
E Rekka1, S Retsas, V J Demopoulos
1Department of Pharmaceutical Chemistry, School of Pharmacy, University of Thessaloniki, Greece.
Archiv Der Pharmazie
|January 1, 1990
Abstract:
Some substituted 2-alkoxy-morpholines have been synthesized as potential antinociceptive agents. These compounds share some structural characteristics of the piperidine analgesics. Their lipophilicity, expressed as log P (octanol-water) and as RM values (from reversed phase thin layer chromatography) was determined. Correlation of these two lipophilicity parameters indicated the classification of the tested compounds into two subgroups. Acute toxicity and, for some selected structures, analgesic activity are reported.