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Extramammary Paget disease: epidemiology and association to cancer in a Quebec-based population
Deana Funaro1, Mark Krasny, Christina Lam
1Division of Vulvar Disease, Centre Hospitalier Universitaire de Montréal, University of Montreal, Québec, Canada H2X 3J4. rouleaufunaro@videotron.ca
Objective:
This study aimed to further characterize the epidemiology, clinical manifestations, pathology, immunopathology, outcome from therapy, and associated underlying malignancy in extramammary Paget disease (EMPD).
Materials And Methods:
We conducted a retrospective review of patients treated for EMPD in our tertiary care center during a 23-year period ranging from 1985 to 2008.
Results:
Sixty-four cases of EMPD were diagnosed during this period. Mean age at diagnosis was 66.8 years. Of the patients, 79.7% were female. Tumors were mostly localized on the vulvoperineal region. Associated cancers were found in 30% of the patients and included breast cancer and urogenital cancers. Of the patients, 42% had a least 1 recurrence. The risk of recurrence could only be associated to tumor location on the vulvoperineal region. The limitations of this study include its retrospective nature and sample size.
Conclusions:
Extramammary Paget disease is more commonly found on the vulva of older women and frequently recurs. Recurrence was not associated to margin status, which would support a more conservative therapeutic approach.
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