Related Experiment Video
Updated: May 14, 2026

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
Published on: July 20, 2019
Tumor necrosis factor inhibitor-induced serositis
Narender Annapureddy1, Shiv Kumar Agarwal, Natraj Ammakkanavar
11Department of Rheumatology, The Orthopedic Building at Rush University Medical Center, Rush University Medical Center, Chicago, IL; 2Department of Medicine, St. Luke's-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, NY; 3Department of Hematology/Oncology, Indiana University, Indianapolis, IN; 4Department of Gastroenterology, Kansas City VA Medical Center, Kansas City, MO; 5Department of Cardiology, Albert Einstein College of Medicine, Bronx, NY; 6Osmania Medical College, Hyderabad, India; and 7Department of Nephrology, The Mount Sinai School of Medicine, New York, NY.
A patient on adalimumab developed unexplained pleural effusion, a form of serositis. Treatment with corticosteroids led to recovery, suggesting an immune-related adverse effect.
Area of Science:
- Rheumatology
- Pulmonology
- Immunology
Background:
- Adalimumab is a TNF-alpha inhibitor used for autoimmune conditions like psoriatic arthritis.
- Pleural effusion can be a rare complication of biologic therapies.
- Accurate diagnosis is crucial for appropriate management.
Observation:
- A 46-year-old man with asthma and psoriatic arthritis presented with fever, tachycardia, and hypoxia.
- He was diagnosed with exudative pleural effusion and initially treated with antibiotics without improvement.
- Blood and pleural fluid cultures were negative.
Findings:
- The patient showed remarkable recovery after initiating prednisone treatment.
- The condition was diagnosed as adalimumab-induced serositis.
- This highlights a potential immune-related adverse event of adalimumab therapy.
Implications:
- Adalimumab-induced serositis should be considered in patients on this biologic agent presenting with unexplained pleural effusions.
- Corticosteroid therapy may be effective in managing this condition.
- Further research into the mechanisms of biologic-induced serositis is warranted.
More Related Videos
16:07Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
Published on: September 16, 2017
09:32Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity
Published on: October 17, 2025
Related Concept Videos
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Tumor Immunotherapy
Inflammatory Bowel Disease II: Ulcerative Colitis
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Hypersensitivity Reactions: Cytolytic Reactions
Drug Toxicity: Allergic Reactions