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Updated: May 14, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Synthesis of new optically active 2-pyrrolidinones
Panagiota Moutevelis-Minakakis1, Eleni Papavassilopoulou, Thomas Mavromoustakos
1Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Athens, Greece. pminakak@chem.uoa.gr
Abstract:
A new class of optically active 2-pyrrolidinones was synthesized, starting from S-pyroglutamic acid, a well known natural chiral synthon. The synthetic design followed led to the insertion of various substituents at positions 1 and 5 of the 2-pyrrolidinone ring, including the imidazole moiety. Some of them possess two or three stereogenic centers, the configuration of which was retained under the mild conditions used. The new compounds also carry an imidazole moiety, which, along with the 2-pyrrolidinone template, may prove pivotal to several biological processes.
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