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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
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Epidemiological risk factors in microscopic colitis: a prospective case-control study.

Fernando Fernández-Bañares1, Monia R de Sousa, Antonio Salas

  • 1Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Terrassa, Spain. ffbanares@mutuaterrassa.es

Inflammatory Bowel Diseases
|January 25, 2013
PubMed
Summary

Epidemiological risk factors for collagenous colitis (CC) and lymphocytic colitis (LC) were identified. Current smoking, certain medications, and autoimmune diseases are associated with microscopic colitis risk.

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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Area of Science:

  • Gastroenterology
  • Epidemiology

Background:

  • The etiology of collagenous colitis (CC) and lymphocytic colitis (LC) remains unknown.
  • Epidemiological risk factors for CC and LC require further investigation.

Purpose of the Study:

  • To identify and evaluate epidemiological risk factors associated with collagenous colitis (CC) and lymphocytic colitis (LC) using a case-control study design.

Main Methods:

  • A case-control study was conducted involving 120 patients with CC, 70 with LC, and 128 controls.
  • Prospective data collection was performed for all participants.
  • Binary logistic regression analysis was employed to assess risk factors for CC and LC separately.

Main Results:

  • For CC, independent risk factors included current smoking (OR, 2.4), polyarthritis history (OR, 20.8), and use of lansoprazole (OR, 6.4), low-dose aspirin (OR, 3.8), beta-blockers (OR, 3.6).
  • For LC, independent risk factors included current smoking (OR, 3.8), autoimmune diseases (OR, 8), and use of sertraline (OR, 17.5), omeprazole (OR, 2.7), low-dose aspirin (OR, 4.7).
  • Protective associations were noted for angiotensin II receptor antagonists in CC (OR, 0.20) and oral antidiabetic drugs in LC (OR, 0.14).

Conclusions:

  • Drug consumption, current smoking status, and the presence of autoimmune diseases are independently associated with an increased risk of microscopic colitis.
  • These findings highlight specific modifiable and non-modifiable factors contributing to the development of CC and LC.