Monitoring time interval for pQCT-derived bone outcomes in postmenopausal women
R L Duckham1, A W Frank, J D Johnston
1College of Kinesiology, University of Saskatchewan, Saskatoon, SK, Canada.
Summary
Longitudinal studies require careful monitoring intervals. Bone density and strength in postmenopausal women necessitate 2-6 year monitoring periods at the radius and tibia for accurate tracking.
Area of Science:
- Bone densitometry and osteoporosis research.
- Biomechanical analysis of bone properties.
Background:
- Longitudinal studies rely on precise measurements and understanding annual changes.
- Monitoring time intervals (MTIs) are crucial for interpreting study results.
Purpose of the Study:
- To determine the precision error, annual change, and optimal MTI for bone density, area, and strength parameters.
- To inform the design and interpretation of longitudinal studies in postmenopausal women.
Main Methods:
- Analysis of annual peripheral quantitative computed tomography (pQCT) scans from 114 postmenopausal women over 2 years.
- Calculation of median annualized percent change and MTIs for various bone parameters.
- Determination of precision error using root mean squared coefficients of variation (CV%) from duplicate scans.
Main Results:
- Precision errors (CV%) ranged from 0.7% to 6.1% across different bone sites and parameters.
- Calculated MTIs varied from 2 to 6 years for radius and tibia bone properties.
- Specific MTIs were determined for total bone density, area, and strength indices at distal and diaphyseal sites.
Conclusions:
- Longitudinal studies in postmenopausal women require MTIs of 2-6 years for radius and tibia.
- Monitoring should focus on total and trabecular bone area, total density, and bone strength.
- These findings are essential for accurate interpretation of bone changes in aging women.
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