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A protein concentration measurement system using a flexural plate-wave frequency-shift readout technique.

Chua-Chin Wang¹, Tzu-Chiao Sung, Chia-Hao Hsu

¹Department of Electrical Engineering, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan. ccwang@ee.nsysu.edu.tw

Sensors (Basel, Switzerland)

|January 25, 2013

Summary

This study presents a novel protein concentration measurement system using flexural plate-wave (FPW) biosensors and a frequency-shift readout technique. The system accurately detects frequency shifts for precise protein quantification.

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Area of Science:

Biomedical Engineering
Sensor Technology
Integrated Circuits

Background:

Accurate protein concentration measurement is crucial for diagnostics and research.
Existing methods may face limitations in sensitivity or integration.

Purpose of the Study:

To develop and demonstrate a protein concentration measurement system utilizing flexural plate-wave (FPW) biosensors.
To implement a frequency-shift readout technique for enhanced sensitivity and accuracy.

Main Methods:

The system employs two-port FPW biosensors with a peak detecting scheme for frequency shift measurement.
A linear frequency generator (2-10 MHz), peak detectors, registers, and a subtractor form the readout circuit.
The circuit is fabricated on silicon using a standard 0.18 μm CMOS technology.

Main Results:

The frequency-shift readout circuit demonstrates a sensitivity of 10 mV for peak detectors.
The protein concentration measurement system exhibits a power consumption of 48 mW at a 0.1 MHz system clock.

Conclusions:

The proposed system offers a viable solution for protein concentration measurement using FPW biosensors.
The integrated CMOS circuit enables efficient and sensitive frequency shift detection for biosensing applications.