Morphological studies on the subchronic toxicity of a standardized liver- and spleen-extract

Related Experiment Video

Updated: Oct 22, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

G H Leder1, O Leder

  • 1Anatomisches Institut der Universität, Freiburg, Fed. Rep. of Germany.

Arzneimittel-Forschung
|February 1, 1990
PubMed

Abstract:

A short-term safety study on the liver- and spleen-extract Factor AF2 has been carried out. Daily injections of 4 or 33.3 mg/kg body weight for six weeks were not followed by drug-induced changes.

More Related Videos

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure
08:25

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

Published on: June 5, 2020

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

Related Experiment Videos

Last Updated: Oct 22, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure
08:25

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

Published on: June 5, 2020

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

Related Concept Videos

Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

Articles linked to this work by shared authors, journal, and citation graph.

Theoretical considerations and in vitro concentration response studies with two human colorectal carcinoma cell lines. The rational experimental base for clinical studies in regional chemotherapy.

Gan to kagaku ryoho. Cancer & chemotherapy·2000

Palliative and adjuvant regional chemotherapy in pancreatic cancer.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·1997

Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy.

Cancer letters·1997

Regional chemotherapy directed by individual chemosensitivity testing in vitro: a prospective decision-aiding trial.

Clinical cancer research : an official journal of the American Association for Cancer Research·1996

Inhibition of nitric oxide synthesis does not improve interleukin-2-mediated antitumor effects in vivo.

European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes·1996

Addition of interleukin 12 to low dose interleukin 2 treatment improves antitumor efficacy in vivo.

Zeitschrift fur Gastroenterologie·1995

Leave-one-out procedure in the validation of elimination rate constant analysis.

Arzneimittel-Forschung·2012

Pharmacokinetic and myocardial enzyme profiles of two administration routes of epirubicin in breast cancer patients.

Arzneimittel-Forschung·2012

Synthesis, anti-hypertensive effect of a novel angiotensin II AT1 receptor antagonist and its anti-tumor activity in prostate cancer.

Arzneimittel-Forschung·2012

Effect of zeolite nano-materials and artichoke (Cynara scolymus L.) leaf extract on increase in urinary clearance of systematically absorbed nicotine.

Arzneimittel-Forschung·2012

Fluorescence detection of etoposide-loaded nanoparticles by HPLC and pharmacokinetics study.

Arzneimittel-Forschung·2012

Pharmacokinetics and potential advantages of a new oral solution of levothyroxine vs. other available dosage forms.

Arzneimittel-Forschung·2012

Investigation of cellular DNA repair capacity with an inhibitor-modified comet assay.

Mutagenesis·2026

Water-ice coexistence under nanoscale confinement revealed by magnetization-transfer NMR.

The Journal of chemical physics·2026

Lipid-coated water-in-oil droplets as a passivation-free platform for cost-effective fluorescence spectroscopy.

Lab on a chip·2026

Shockwave Lithotripsy for Severe Calcified Extracranial Vertebral and Carotid Disease Treated With Percutaneous Stenting.

Stroke (Hoboken, N.J.)·2026

Conus hematoma following spinal anesthesia in an unrecognized case of occult spinal dysraphism: Lessons from a rare but preventable iatrogenic injury.

Surgical neurology international·2026

Diagnostic and Management Challenges in Xanthogranulomatous Pyelonephritis: A Case Report.

Cureus·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us