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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

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Related Experiment Video

Updated: May 14, 2026

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

[Epidemiology of anaphylaxis].

M Worm1

  • 1Klinik für Dermatologie, Venerologie und Allergologie, Allergie-Centrum-Charité, Charité-Universitätsmedizin Berlin. margitta.worm@charite.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|January 25, 2013
PubMed
Summary

Anaphylaxis, a severe allergic reaction, is increasing, with venom, drugs, and foods as common triggers. Understanding risk factors like asthma and medications is crucial for optimizing patient management.

Area of Science:

  • Allergy and Immunology
  • Epidemiology
  • Mast Cell Biology

Background:

  • Anaphylaxis is a severe, mast cell-dependent hypersensitivity reaction.
  • Epidemiological data show an increase in food and drug-induced anaphylaxis.
  • Global incidence and triggers vary due to endogenous and exogenous factors.

Purpose of the Study:

  • To analyze epidemiological data on anaphylaxis in German-speaking countries.
  • To identify frequent elicitors and risk factors for anaphylaxis.
  • To provide data for optimizing patient management and treatment strategies.

Main Methods:

  • Analysis of data from an anaphylaxis registry in German-speaking regions.
  • Identification of common elicitors (venom, drugs, foods) and age-dependent trends.

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  • Evaluation of risk factors including comorbidities (asthma, mastocytosis), age, gender, medications (ACE inhibitors, aspirin), and exercise.

    • Main Results:

    • Venom, drugs, and foods are the most frequent anaphylaxis elicitors in German-speaking countries.
    • Elicitor ranking is age-dependent.
    • Comorbidities, certain medications, and exercise are identified as significant risk factors.

    Conclusions:

    • Clinical epidemiological data are essential for tracking anaphylaxis trends and improving patient care.
    • The anaphylaxis registry provides valuable insights into elicitors, risk factors, and treatment.
    • Optimized management strategies are needed for this potentially fatal IgE-dependent condition.