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Mean platelet volume as a predictor for long-term outcome after percutaneous coronary intervention

Alon Eisen1, Tamir Bental, Abid Assali

  • 1Cardiology Department, Rabin Medical Center, 39 Jabotinsky St., 49100, Petah Tikva, Israel, a_alon1@netvision.net.il.

Journal of Thrombosis and Thrombolysis
|January 25, 2013
PubMed

Insights

Elevated mean platelet volume (MPV) predicts adverse cardiac events in patients undergoing percutaneous coronary intervention (PCI). This finding holds true for both elective and urgent PCI procedures, highlighting MPV as a significant prognostic marker for mortality and major adverse cardiovascular events.

Area of Science:

  • Cardiology
  • Hematology
  • Clinical Research

Background:

  • Mean platelet volume (MPV) is a readily available parameter from complete blood counts.
  • Increased MPV correlates with heightened platelet reactivity and adverse cardiac outcomes, particularly in acute coronary syndromes (ACS).
  • Prognostic significance of baseline MPV in a large, diverse patient population undergoing percutaneous coronary intervention (PCI) remains under-explored.

Purpose of the Study:

  • To investigate the predictive value of baseline MPV for clinical outcomes in patients undergoing PCI.
  • To assess the association between MPV and long-term adverse cardiovascular events following PCI.

Main Methods:

  • A cohort of 7,585 consecutive patients undergoing PCI between 2004-2010 was analyzed.
  • Baseline MPV was measured before angiography, with clinical outcomes followed for a median of 4 years.
  • Multivariate analysis was employed to evaluate the association between MPV and clinical endpoints, including mortality and a composite of death, myocardial infarction (MI), and target vessel revascularization.

Main Results:

  • Mean MPV was higher in women, diabetic patients, and those admitted with ACS compared to respective controls.
  • On multivariate analysis, MPV was significantly associated with mortality (HR 1.18) and a composite endpoint (HR 1.09).
  • Elevated MPV predicted mortality in both elective and urgent PCI patients (HR 1.30 and HR 1.13, respectively).

Conclusions:

  • Baseline mean platelet volume is a significant independent predictor of adverse cardiovascular events, including mortality, in patients undergoing PCI.
  • Elevated MPV serves as a valuable prognostic marker for both elective and urgent PCI procedures.
  • MPV measurement offers a simple yet powerful tool for risk stratification in patients undergoing interventional cardiology procedures.

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