Numerical investigation of axonal cargo rerouting in a dendrite: a three kinetic state model

The purpose of this paper is to develop a three-kinetic state model to investigate axonal cargo rerouting in a dendrite. It is assumed that axonal cargos are transported by kinesin motors; they can enter dendrites riding on plus-end-out microtubules (MTs). If this happens, cargos are rerouted by dissociating from these MTs and associating with minus-end-out MTs. The same kinesin motors then move axonal cargos out of the dendrite. The model predicts how far axonal cargos can penetrate into the dendrite, concentrations of various populations of axonal cargos, and cargo fluxes.