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06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Recurrent transient ischaemic attack and early risk of stroke: data from the PROMAPA study
Francisco Purroy1, Pedro Enrique Jiménez Caballero, Arantza Gorospe
1Stroke Unit, Department of Neurology, Universitat de Lleida, Hospital Universitari Arnau de Vilanova de, Lleida, IRBLleida, Avda Rovira Roure, 80, Lleida 25198, Spain. fpurroygarcia@gmail.com
Journal of Neurology, Neurosurgery, and Psychiatry
|January 25, 2013
Summary
Patients experiencing multiple transient ischaemic attacks (TIAs) within 7 days face a higher stroke risk. However, no specific factors predict stroke recurrence in these individuals.
Area of Science:
- Neurology
- Vascular Medicine
- Stroke Prevention
Background:
- Guidelines recommend urgent intervention for patients with multiple transient ischaemic attacks (TIAs) within 7 days to mitigate early stroke risk.
- The PROMAPA study investigated the stroke risk associated with multiple TIAs.
Purpose of the Study:
- To evaluate if all patients with multiple TIAs share the same elevated early stroke risk.
- To identify predictors of stroke recurrence in patients with multiple TIAs.
Main Methods:
- A prospective study of 1255 patients with TIA from 30 Spanish stroke centers (April 2008-December 2009).
- Clinical characteristics and short-term stroke risk (7 and 90 days) were recorded.
- Etiology was classified using the TOAST criteria.
Main Results:
- The 7-day and 90-day stroke risk were 2.6% and 3.8% respectively in the overall TIA cohort.
- Multiple TIAs occurred in 24.1% of patients. Predictors included short duration, large-artery atherosclerosis (LAA), and motor weakness.
- Patients with multiple TIAs had a significantly higher stroke risk at 7 days (5.9%) and 90 days (6.8%) compared to single TIA patients.
Conclusions:
- Multiple TIAs within 7 days are linked to a greater subsequent stroke risk than single TIAs.
- No independent predictors of stroke recurrence were identified among patients with multiple TIAs.
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