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Laminar Flow-based Assays to Investigate Leukocyte Recruitment on Cultured Vascular Cells and Adherent Platelets
Published on: April 9, 2018
Getting leukocytes to the site of inflammation
1Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. wamuller@northwestern.edu
Veterinary Pathology
|January 25, 2013
Summary
Leukocyte transendothelial migration, or diapedesis, is crucial for immune responses. This review details the molecular mechanisms governing both paracellular and transcellular pathways, highlighting shared regulatory molecules.
Area of Science:
- Immunology
- Cell Biology
Background:
- Immune cell trafficking across blood vessels is essential for innate and adaptive immunity.
- Leukocyte diapedesis involves movement through or between endothelial cells.
Purpose of the Study:
- To review the molecular mechanisms of leukocyte transendothelial migration.
- To focus on the molecules and pathways regulating both paracellular and transcellular migration.
Main Methods:
- Literature review of studies on leukocyte diapedesis.
- Analysis of molecular regulators of endothelial transmigration.
Main Results:
- Diapedesis is critical for initiating immune responses.
- Both paracellular and transcellular migration share common molecular regulators.
- The lateral border recycling compartment plays a significant role in transmigration.
Conclusions:
- A unified hypothesis for leukocyte transmigration mechanisms is proposed.
- Understanding these pathways is key to modulating immune cell trafficking.
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