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Updated: May 14, 2026

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
Published on: July 24, 2021
Old drugs: new complications
Sandeep Batra1, Jyoti Wadhwa, Ashok K Vaid
1Department of Medical Oncology, Medanta, The Medicity, Gurgaon, Haryana, India. sandeepriya2000@yahoo.com
Abstract:
This is a case of acute splenic and bilateral renal infarction in a patient with non-small cell lung carcinoma during chemotherapy with gemcitabine and cisplatin. Till date, bilateral renal infarction following gemcitabine and cisplatin has been reported only once in the past. The case that is being reported has had acute splenic and bilateral renal infarct and has not been reported previously. Splenic and renal infarction should be considered in the differential diagnosis of excruciating abdominal pain and backache in a patient on gemcitabine-based and cisplatin-based chemotherapy.
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