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Updated: May 14, 2026

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Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
Published on: December 18, 2012
Susceptibility of human iris stromal cells to herpes simplex virus 1 entry
John Baldwin1, Paul J Park, Brian Zanotti
1Department of Microbiology & Immunology, Midwestern University, Downers Grove, Illinois, USA.
Journal of Virology
|January 25, 2013
Abstract:
Ocular herpes simplex virus 1 (HSV-1) infection can lead to multiple complications, including iritis, an inflammation of the iris. Here, we use human iris stroma cells as a novel in vitro model to demonstrate HSV-1 entry and the inflammatory mediators that can damage the iris. The upregulated cytokines observed in this study provide a new understanding of the intrinsic immune mechanisms that can contribute to the onset of iritis.

