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Related Concept Videos

Tooth Anatomy01:21

Tooth Anatomy

The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
Teeth01:15

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
Oral Cavity01:11

Oral Cavity

The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Psychosexual Stages of Personality: Oral01:16

Psychosexual Stages of Personality: Oral

The oral stage is the initial phase of Sigmund Freud's theory of psychosexual development, occurring from birth to approximately 12 to 18 months. During this period, the infant's mouth serves as the primary source of pleasure, with actions such as sucking, chewing, biting, and drinking playing a crucial role in reducing tension. These activities are essential not only for nourishment but also for the infant's psychological and emotional satisfaction.
Weaning, typically occurring around the age...
Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...

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Related Experiment Video

Updated: May 14, 2026

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology
07:26

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology

Published on: August 22, 2022

Tooth eruption without roots.

X-P Wang1

  • 1Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA. xiuping_wang@hsdm.harvard.edu

Journal of Dental Research
|January 25, 2013
PubMed
Summary
This summary is machine-generated.

Root development and tooth eruption are crucial in dentistry but poorly understood. Transgenic mouse models offer a new way to study the genetic and molecular basis of these processes for better dental therapies.

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Area of Science:

  • Dentistry
  • Developmental Biology
  • Genetics

Background:

  • Root development and tooth eruption are fundamental to dental health.
  • These processes are complex and remain incompletely understood.
  • Limited genes have been identified in relation to root formation and eruption.

Purpose of the Study:

  • To highlight the importance of root development and tooth eruption.
  • To address the challenges in studying these late-stage developmental processes.
  • To propose the use of transgenic mouse models for further research.

Main Methods:

  • Review of current understanding of root development and tooth eruption.
  • Discussion of challenges in studying these processes.
  • Introduction of transgenic mouse models as a research tool.

Main Results:

  • Dental follicle and bone remodeling are essential for tooth eruption.
  • Difficulties in studying late developmental stages and lack of model systems hinder research.
  • Transgenic mice with eruption defects serve as valuable models.

Conclusions:

  • Further research using advanced models is needed to understand root formation and tooth eruption.
  • Deciphering cellular, molecular, and genetic mechanisms is key.
  • Improved understanding can lead to more effective future dental therapies.