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Knee Arthrocentesis in Adults

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Published on: February 25, 2022

Low-dose aspirin use and recurrent gout attacks.

Yuqing Zhang¹, Tuhina Neogi, Clara Chen

¹Clinical Epidemiology Research and Training Unit, Department of Medicine, Boston University School of Medicine, , Boston, Massachusetts, USA.

Annals of the Rheumatic Diseases

|January 25, 2013

Summary

Low-dose aspirin use, especially on consecutive days, significantly increases the risk of recurrent gout attacks. Concomitant use of allopurinol may mitigate this effect in gout patients.

Keywords:

Epidemiology Gout Treatment

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Area of Science:

Rheumatology
Cardiology
Pharmacology

Background:

Gout is a painful inflammatory arthritis characterized by hyperuricemia.
Low-dose aspirin is frequently used for cardioprotection, but its effect on gout flares is not well understood.

Purpose of the Study:

To investigate the association between low-dose aspirin use and the risk of recurrent gout attacks.

Main Methods:

An online case-crossover study involving individuals with gout over one year.
Data collected included medication use (aspirin dosage), symptoms, and exposure during gout attacks and control periods.

Main Results:

Aspirin use (≤325 mg/day) on two consecutive days was associated with an 81% increased risk of gout attacks (OR=1.81).
Lower aspirin doses showed stronger associations, with an OR of 1.91 for doses ≤100 mg.
Allopurinol use nullified the increased risk of gout attacks associated with aspirin.

Conclusions:

Consecutive use of low-dose aspirin is linked to a higher risk of recurrent gout attacks.
Monitoring serum urate and adjusting urate-lowering therapy are crucial for gout patients using low-dose aspirin.