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Updated: May 14, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
Energy profile of the space of model protein sequences
G Tiana1, R A Broglia, E I Shakhnovich
1The Niels Bohr Institute, University of Copenhagen, Bledgamsvej 16, 2100 Copenhagen, Denmark ; Department of Chemistry, Harvard University, 16 Oxford st., Cambridge, MA USA.
Abstract:
A numerical study of the energy landscape of the space of model proteinsequences is carried out. As a consequence of the heterogeneity of thecontact energies among amino acids, the energy landscape displays a veryrough profile, a behaviour typical of frustrated systems. This givesraise to a hierarchical clustering of low-energy sequences and can have evolutionary consequences.
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