Related Experiment Video
Updated: May 14, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
Published on: January 16, 2016
Different scenarios for inter-protein electron tunneling: the effect of water-mediated pathways
O Miyashita1, H L Axelrod, J N Onuchic
1University of California, San Diego, 9500 Gilman Dr, La Jolla, California U.S.A.
Abstract:
Recent theoretical developments now allow for reliable calculation oftunneling matrix elements in unimolecular biological electron transferreactions that have been tested experimentally. Most biological ETprocesses, however, are bimolecular, or involve large-scale proteindomain motions. In this paper, initial advances in this direction bystudying the inter-protein electron transfer between cytochrome c(2)andthe photosynthetic reaction center. Utilizing an approach that integratesmolecular dynamics and the Pathways method, we have observed that theensemble dominant tunneling pathways in this reaction go though thetyrosine 162 or are water mediated.
More Related Videos
Related Concept Videos
ATP Driven Pumps I: An Overview
There are four main types of ATP-driven pumps - P-type, V-type, F-type, and ABC transporter. All these pumps are of varying complexities and are...
Electron Transport Chain Components
Aquaporins
ATP Synthase: Mechanism
Chemiosmosis and ATP Synthesis
Energy to Drive Translocation
Generally, polypeptides are unfolded by two distinct...

