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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
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Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
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The Michaelis–Menten equation is a fundamental model for describing capacity-limited kinetics in drug metabolism. It offers insights into the rate of decline of plasma drug concentration Cp over time, with Vmax and KM as pivotal parameters.
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Related Experiment Video

Updated: May 14, 2026

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

Cell Simulation for Circadian Rhythm Based on Michaelis-MentenModel.

S V Sabau, S Hashimoto, Y Nemoto

    Journal of Biological Physics
    |January 25, 2013
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces a cell biology simulator to model circadian rhythms. Simulations reveal heat pulses

    Keywords:
    Circadian rhythmfourth order Runge-Kutta methodregulatory pathway

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    Published on: November 11, 2016

    Area of Science:

    • Cellular Biology
    • Systems Biology
    • Computational Biology

    Background:

    • Circadian rhythms are endogenous biological processes crucial for regulating daily physiological activities.
    • Understanding the molecular mechanisms underlying circadian rhythms, particularly in response to environmental stimuli, is essential.
    • Drosophila melanogaster serves as a powerful model organism for studying circadian biology due to its conserved genetic pathways.

    Purpose of the Study:

    • To develop a novel cell biological simulation system based on ordinary differential equations.
    • To simulate the effects of heat pulses on the circadian rhythm in Drosophila.
    • To elucidate the role of specific molecules, such as dClk mRNA, in the phase-shift response.

    Main Methods:

    • Development of a simulation system incorporating intra-cellular processes: transcription, translation, transport, modification, and degradation.
    • Modeling of the circadian rhythm in Drosophila using ordinary differential equations.
    • Simulation of heat pulse effects on circadian clock proteins PER and TIM.

    Main Results:

    • The simulation system accurately models temporal changes in protein and mRNA concentrations.
    • Simulations demonstrated the robustness of the Drosophila circadian genetic network.
    • Heat pulses applied in early afternoon significantly impact PER and TIM protein levels, highlighting the role of dClk mRNA.

    Conclusions:

    • The developed simulator is a valuable tool for studying complex biological systems and intracellular processes.
    • The study underscores the critical role of dClk mRNA in mediating phase-shift responses to heat pulses in Drosophila.
    • The findings contribute to a deeper understanding of circadian rhythm robustness and environmental influences.