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Determination of Glucose Concentration in Whole Blood using Fourier-Transform Infrared Spectroscopy
Y C Shen1, A G Davies, E H Linfield
1Cavendish Laboratory, University of Cambridge, Madingley Road, Cambridge, CB3 0HE UK.
Abstract:
Fourier-transform infrared(FTIR) transmission spectroscopy has beenused for the determination of glucoseconcentrations in whole blood samples fromtwenty-eight patients. A four-vectorpartial least squares calibration model,using the spectral range 950-1200 cm(-1),yielded a standard error of prediction of0.59 mM for an independent test set. Forblood samples from a single patient, wefound that the glucose concentration wasproportional to the difference between thevalues of the second derivative spectrum at1082 cm(-1) and 1093 cm(-1), suggestingthat these two specific wavelengths can beused for determining glucose concentrationsin blood.
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