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Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 
Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents01:17

Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents

Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...

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Updated: May 14, 2026

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
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Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

Lubiprostone induced ischemic colitis.

Muhammed Sherid1, Humberto Sifuentes, Salih Samo

  • 1Department of Internal Medicine, Division of Gastroenterology, Saint Francis Hospital, Evanston, IL 60202, United States.

World Journal of Gastroenterology
|January 25, 2013
PubMed
Summary
This summary is machine-generated.

Lubiprostone, a medication for constipation, may cause ischemic colitis, a condition involving reduced blood flow to the colon. This case report highlights the importance of considering lubiprostone when patients present with abdominal pain and rectal bleeding.

Keywords:
ColonoscopyGastrointestinal bleedingIschemic colitisLubiprostoneRectal bleeding

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Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
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Area of Science:

  • Gastroenterology
  • Colorectal Medicine
  • Clinical Pharmacology

Background:

  • Ischemic colitis is a significant cause of acute lower gastrointestinal bleeding, often multifactorial and prevalent in the elderly.
  • Various medications are known to precipitate colonic ischemia, necessitating careful review of drug histories in affected patients.

Observation:

  • A 54-year-old woman experienced acute nausea, vomiting, abdominal pain, and bloody stool shortly after initiating lubiprostone.
  • A strong temporal association was observed between an increased dose of lubiprostone and the onset of her rectal bleeding and other symptoms.

Findings:

  • Radiological, colonoscopic, and histopathological examinations confirmed ischemic colitis as the diagnosis.
  • The patient's symptoms resolved completely without complications upon discontinuation of lubiprostone, establishing a clear causal link (Naranjo score of 10).

Implications:

  • This case represents the first documented instance of ischemic colitis directly linked to lubiprostone use.
  • Clinicians should maintain a high index of suspicion for ischemic colitis in patients on lubiprostone presenting with abdominal pain and rectal bleeding.