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Updated: May 14, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
10:28

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Published on: March 15, 2022

Physiologic approach for coronary intervention.

William F Fearon1

  • 1Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA 94305, USA. wfearon@stanford.edu

The Korean Journal of Internal Medicine
|January 25, 2013
PubMed
Summary
This summary is machine-generated.

Fractional flow reserve (FFR) accurately identifies coronary artery disease causing symptoms and future cardiac events. FFR-guided treatment improves outcomes for significant lesions, while non-significant ones can be managed medically.

Keywords:
Coronary diseaseCoronary physiology

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Area of Science:

  • Cardiology
  • Interventional Cardiology

Background:

  • Assessing coronary artery disease invasively requires identifying symptom-causing and prognostically significant lesions.
  • Myocardial ischemia is the key indicator of lesion significance for symptoms and future cardiac events.

Purpose of the Study:

  • To highlight the role of Fractional Flow Reserve (FFR) as the reference standard in identifying ischemia-producing coronary artery lesions.
  • To emphasize the benefits of FFR-guided percutaneous coronary intervention and medical management.

Main Methods:

  • Utilizing a coronary pressure wire to measure FFR in the catheterization laboratory.
  • Assessing lesion-specific ischemia with high spatial resolution.

Main Results:

  • FFR is the gold standard for identifying ischemia-producing lesions, offering vessel-specific and lesion-specific accuracy.
  • FFR-guided percutaneous coronary intervention improves patient outcomes and resource utilization.
  • Non-hemodynamically significant lesions managed medically show a low rate of subsequent cardiac events.

Conclusions:

  • FFR measurement is crucial for accurate diagnosis and guiding treatment in coronary artery disease.
  • FFR-guided revascularization improves outcomes compared to non-guided approaches.
  • Medical management is a safe and effective strategy for non-significant coronary lesions.