Related Experiment Video
Updated: Aug 12, 2026

Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology
Published on: August 22, 2022
Orofacial manifestations of mixed connective tissue disease
E Varga1, E A Field, W R Tyldesley
1Department of Dental Surgery, School of Dental Surgery, University of Liverpool.
Abstract:
Mixed connective tissue disease (MCTD) is a multisystem disorder with overlapping features of systemic lupus erythematosus, scleroderma and polymyositis and is differentiated from them by a high titre of antibody to ribonucleoprotein. Orofacial manifestations of MCTD include trigeminal neuralgia-like pain, neuropathy, features suggestive of Sjögren's syndrome and lymphadenopathy. The recent experience of two patients presenting with trigeminal neuropathy as an early manifestation of this disease is described. One of these patients presented with 'lichenoid' oral mucosal lesions as a further early manifestation of MCTD. This appears to be the first case with this presenting feature to be described in the literature.
Related Concept Videos
Assessment of Airway, Skin Color, and Use of Accessory Muscles
Introduction
The initial evaluation of a patient's respiratory system...
Assessment of the Mouth
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
Endocarditis II: Clinical Features of Infective Endocarditis
Chronic Kidney Disease II: Clinical Manifestations
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations
Inflammatory Bowel Disease IV: Clinical Manifestations

