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Updated: May 14, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
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A modified COMS plaque for iris melanoma.

Daniel J Scanderbeg1, Deepta Vasudev, Roger K Rice

  • 1Department of Radiation Oncology and Center for Advanced Radiotherapy Technologies (CART).

Journal of Contemporary Brachytherapy
|January 25, 2013
PubMed
Summary
This summary is machine-generated.

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A rare diffuse iris melanoma case required a modified radiation plaque for corneal placement. This novel approach ensured excellent patient tolerance and effective treatment delivery for this ocular tumor.

Area of Science:

  • Ophthalmology
  • Oncology
  • Radiation Therapy

Background:

  • Iris melanoma is a rare ocular tumor, distinct from more common posterior uveal melanomas.
  • Standard Collaborative Ocular Melanoma Study (COMS) plaques are designed for posterior tumors, posing challenges for anterior segment applications like iris melanoma.

Observation:

  • A 51-year-old female presented with diffuse iris melanoma, necessitating radiation therapy.
  • Traditional COMS plaques required modification for optimal placement and conformance on the cornea.

Findings:

  • A novel modification of the traditional COMS plaque was successfully engineered for corneal application.
  • The modified plaque was placed without complication and delivered radiation therapy effectively.
  • The patient demonstrated excellent tolerance to the adapted plaque during treatment.
Keywords:
COMSbrachytherapyeye plaqueiris melanoma

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Implications:

  • This case demonstrates a successful adaptation of established radiation technology for a rare anterior segment malignancy.
  • The modified plaque offers a viable solution for delivering targeted radiotherapy to diffuse iris melanoma.
  • Further research may explore wider applications of modified COMS plaques for other anterior segment ocular tumors.