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Related Experiment Video

Updated: May 14, 2026

Quantitative Autonomic Testing
11:40

Quantitative Autonomic Testing

Published on: July 19, 2011

Autonomic function tests: some clinical applications.

Phillip A Low1, Victoria A Tomalia, Ki-Jong Park

  • 1Department of Neurology, Mayo Clinic, Rochester, MN, USA.

Journal of Clinical Neurology (Seoul, Korea)
|January 25, 2013
PubMed
Summary
This summary is machine-generated.

Modern autonomic function tests accurately assess autonomic failure severity and patterns. These tests aid in diagnosing conditions like autonomic neuropathies and distinguishing synucleinopathies such as Parkinson's disease from multiple system atrophy.

Keywords:
adrenergiccardiovagaldysautonomiasudomotor

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Area of Science:

  • Neurology
  • Autonomic Neuroscience

Background:

  • Autonomic function tests offer non-invasive evaluation of autonomic failure.
  • These tests can detect subclinical dysautonomia and assess severity and distribution.
  • Standard tests cover cardiovagal, sudomotor, and adrenergic functions.

Purpose of the Study:

  • To summarize the utility of autonomic function tests in clinical practice.
  • To highlight their role in diagnosing various autonomic disorders.
  • To differentiate between specific neurological conditions based on autonomic dysfunction patterns.

Main Methods:

  • Cardiovagal function assessed via heart rate response to deep breathing and Valsalva maneuver.
  • Sudomotor function evaluated using quantitative sudomotor axon reflex test and thermoregulatory sweat test.
  • Adrenergic function assessed by blood pressure and heart rate responses to Valsalva and head-up tilt.

Main Results:

  • Autonomic tests define autonomic failure presence, natural history, and treatment response.
  • Patterns of dysautonomia identified aid in diagnosing autonomic neuropathies (e.g., diabetic, amyloidosis) and small fiber neuropathy.
  • Tests distinguish Parkinson's disease (mild failure) from multiple system atrophy (severe generalized failure) and Lewy body dementia (intermediate).

Conclusions:

  • Autonomic function tests are crucial for diagnosing and characterizing autonomic disorders.
  • They provide valuable differential diagnostic information, particularly in synucleinopathies.
  • These tests help classify autonomic failure patterns, aiding in precise diagnosis and management.