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Related Experiment Video

Updated: May 14, 2026

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

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Published on: March 25, 2020

Complement activation and inhibition in wound healing.

Gwendolyn Cazander¹, Gerrolt N Jukema, Peter H Nibbering

¹Department of Surgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands. gwendolyn_cazander@hotmail.com

Clinical & Developmental Immunology

|January 25, 2013

Summary

Inappropriate complement activation worsens chronic wounds. Inhibiting complement offers a promising wound healing strategy, with research exploring natural and synthetic inhibitors for better patient outcomes.

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Last Updated: May 14, 2026

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Published on: August 21, 2020

Area of Science:

Immunology
Wound Healing Research
Biomedical Science

Background:

Complement activation is crucial for tissue repair but can exacerbate chronic wounds by increasing inflammation and cell death.
Dysregulated complement pathways impede effective wound healing, necessitating therapeutic interventions.
Targeting complement offers a novel approach to wound care strategies.

Purpose of the Study:

To review the role of complement activation in wound healing.
To explore the potential of complement inhibitors as a therapeutic strategy for impaired wound healing.
To highlight the need for further preclinical and clinical studies on complement inhibition in wound care.

Main Methods:

Literature review of (pre)clinical studies on complement activation and inhibition in wound healing.
Analysis of existing data on complement inhibitors (e.g., C3, C1, C5 inhibitors) in complement-mediated diseases and wound healing.
Exploration of natural sources (microorganisms, plants) for complement-attenuating agents.

Main Results:

Inappropriate complement activation in chronic wounds contributes to inflammation and delayed healing.
Available data suggest that reducing complement activation can improve wound healing.
Complement inhibitors, including compstatin and C1/C5 inhibitors, are under investigation for various diseases.

Conclusions:

Targeting complement activation is a potential innovative strategy for wound care.
Natural agents from symbionts like medicinal maggots and plants may offer safe complement inhibition.
Further (pre)clinical research is essential to develop effective complement-based wound healing therapies.