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Updated: May 14, 2026
08:52
Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
Published on: May 27, 2011
CMV: Prevention, Diagnosis and Therapy.
1Transplant and Immunocompromised Host Infectious Diseases, Infectious Diseases Division, Massachusetts General Hospital, Boston, MA, USA. ckotton@partners.org
Summary
Cytomegalovirus (CMV) infection is common after organ transplants, impacting patient survival. This review covers optimal prevention, diagnosis, and treatment strategies for CMV to improve transplant outcomes.
Area of Science:
- Transplant Infectious Diseases
- Immunology
- Virology
Background:
- Cytomegalovirus (CMV) is the most frequent infection post-organ transplantation.
- CMV significantly affects patient morbidity, mortality, and graft survival rates.
Purpose of the Study:
- To review and compare optimal strategies for CMV prevention, diagnosis, and treatment in transplant recipients.
- To highlight recent advances in diagnostics and therapeutics for CMV infections.
Main Methods:
- Comparison of universal prophylaxis versus preemptive therapy for CMV prevention.
- Discussion of advancements in CMV diagnostic assays, including international standards and cellular immune function tests.
- Review of current and novel therapeutic agents for CMV, including oral valganciclovir versus intravenous ganciclovir.
Main Results:
- Both universal prophylaxis and preemptive therapy have distinct advantages for CMV prevention.
- Improved diagnostic tools allow for more accurate and timely CMV treatment decisions.
- Oral valganciclovir demonstrates comparable efficacy to intravenous ganciclovir.
- Novel agents are emerging to address challenges in treating resistant CMV.
Conclusions:
- Optimizing CMV prevention, diagnosis, and treatment is crucial for enhancing organ transplant outcomes.
- Advances in diagnostics and therapeutics offer improved management of CMV infections in transplant patients.
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