Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Functional Brain Systems: Limbic System

Functional Brain Systems: Limbic System

The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-β plaque and phosphorylated tau deposition and corresponding behavioral deficits.

GeroScience·2019

Same author

Unfolding the cognitive map: The role of hippocampal and extra-hippocampal substrates based on a systems analysis of spatial processing.

Neurobiology of learning and memory·2017

Same author

An analysis of dentate gyrus function (an update).

Behavioural brain research·2017

Same author

Adaptation of the Arizona Cognitive Task Battery for use with the Ts65Dn mouse model (Mus musculus) of Down syndrome.

Journal of comparative psychology (Washington, D.C. : 1983)·2017

Same author

The ventral dentate gyrus mediates pattern separation for reward value.

Behavioral neuroscience·2016

Same author

Exploration of the Neurobiological Basis for a Three-System, Multiattribute Model of Memory.

Current topics in behavioral neurosciences·2016

Search research articles

Related Experiment Video

Updated: May 14, 2026

Dissection of Hippocampal Dentate Gyrus from Adult Mouse

Dissection of Hippocampal Dentate Gyrus from Adult Mouse

Published on: November 17, 2009

An analysis of the dentate gyrus function.

Raymond P Kesner¹

¹Department of Psychology, University of Utah, 380 South 1530 East, Rm 502, Salt Lake City, UT 84112-0251, USA.

Behavioural Brain Research

|January 26, 2013

Summary

The dorsal dentate gyrus (dDG) processes spatial memory through sensory integration and pattern separation. The ventral dentate gyrus (vDG) handles odor information, crucial for memory recall.

Keywords:

Conjunctive encoding Context Dorsal and ventral dentate gyrus Neurogenesis Remote memory Spatial and odor pattern separation

More Related Videos

In Vivo Calcium Imaging of Granule Cells in the Dentate Gyrus of Hippocampus in Mice

In Vivo Calcium Imaging of Granule Cells in the Dentate Gyrus of Hippocampus in Mice

Published on: August 2, 2024

Assessment of Dendritic Arborization in the Dentate Gyrus of the Hippocampal Region in Mice

Assessment of Dendritic Arborization in the Dentate Gyrus of the Hippocampal Region in Mice

Published on: March 31, 2015

Related Experiment Videos

Last Updated: May 14, 2026

Dissection of Hippocampal Dentate Gyrus from Adult Mouse

Dissection of Hippocampal Dentate Gyrus from Adult Mouse

Published on: November 17, 2009

In Vivo Calcium Imaging of Granule Cells in the Dentate Gyrus of Hippocampus in Mice

In Vivo Calcium Imaging of Granule Cells in the Dentate Gyrus of Hippocampus in Mice

Published on: August 2, 2024

Assessment of Dendritic Arborization in the Dentate Gyrus of the Hippocampal Region in Mice

Assessment of Dendritic Arborization in the Dentate Gyrus of the Hippocampal Region in Mice

Published on: March 31, 2015

Area of Science:

Neuroscience
Cognitive Science
Computational Neuroscience

Background:

The dentate gyrus (DG) plays a critical role in memory formation and retrieval.
Specific subregions, the dorsal DG (dDG) and ventral DG (vDG), are implicated in distinct mnemonic functions.
Understanding these functions requires integrating computational models and behavioral evidence.

Purpose of the Study:

To review the role of the dorsal and ventral dentate gyrus in memory.
To elucidate the specific processes mediated by the dDG in spatial memory.
To highlight the vDG's role in processing olfactory information for memory.

Main Methods:

Review of computational models of dDG function.
Analysis of behavioral evidence from dDG dysfunction studies.
Synthesis of research on neurogenesis and its impact on memory.

Main Results:

The dDG mediates spatial information processing via conjunctive encoding and pattern separation.
Pattern separation in the dDG reduces interference between similar spatial locations and contexts.
The vDG is essential for odor pattern separation and olfactory memory processing.

Conclusions:

The dDG is crucial for spatial memory, involving integration of sensory inputs and pattern separation.
Contextual information and neurogenesis significantly influence spatial memory and remote recall.
The vDG's role in odor pattern separation is vital for olfactory memory.