Related Experiment Video
Updated: May 14, 2026
10:52
Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
Published on: December 17, 2010
Primary antiphospholipid syndrome and panhypopituitarism: a unique presentation
Bárbara Santos Pires da Silva1, Camila Bonin, Cristina Bellotti Formiga Bueno
1Biomedicine, Universidade Cidade de São Paulo, São Paulo, SP, Brazil.
Acta Reumatologica Portuguesa
|January 26, 2013
Summary
This study suggests a potential link between antiphospholipid syndrome (APS) and lymphocytic hypophysitis (LH), a rare pituitary condition. A patient with APS experienced symptoms of panhypopituitarism, indicating a possible new association.
Area of Science:
- Endocrinology
- Rheumatology
- Immunology
Background:
- Lymphocytic hypophysitis (LH) is a rare inflammatory condition affecting the pituitary gland.
- LH is infrequently associated with rheumatic diseases, with limited prior reports linked to antiphospholipid syndrome (APS).
Observation:
- A 34-year-old woman with primary APS presented with polyuria, polydipsia, hypernatremia, and vision impairment.
- Hormone testing revealed panhypopituitarism, and sellar MRI showed a normal pituitary gland with stalk abnormalities.
Findings:
- This case presents the first reported possible association between antiphospholipid syndrome (APS) and lymphocytic hypophysitis (LH).
- The patient's symptoms and imaging findings are consistent with LH in the context of APS.
Implications:
- This potential association may expand the known clinical manifestations of APS.
- Further research is warranted to confirm and understand the relationship between APS and LH.
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