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Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Related Experiment Video

Updated: May 14, 2026

Anterior Cruciate Ligament Transection and Synovial Fluid Lavage in a Rodent Model to Study Joint Inflammation and Posttraumatic Osteoarthritis
06:28

Anterior Cruciate Ligament Transection and Synovial Fluid Lavage in a Rodent Model to Study Joint Inflammation and Posttraumatic Osteoarthritis

Published on: September 2, 2025

Aggressive condylar resorption.

Kaustubh Sansare1, Mamta Raghav, Sanjay Mallya

  • 1Nair Hospital Dental College, Mumbai, India. kaustubhsansare@yahoo.com

The Journal of Craniofacial Surgery
|January 26, 2013
PubMed
Summary

This case study details aggressive unilateral condylar resorption, diagnosed as osteoarthritis. It highlights clinical, imaging, and histopathologic findings, aiding differential diagnosis and management strategies.

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Last Updated: May 14, 2026

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Area of Science:

  • Temporomandibular joint (TMJ) disorders
  • Osteoarthritis research
  • Skeletal biology

Background:

  • Unilateral aggressive condylar resorption presents diagnostic challenges.
  • Distinguishing osteoarthritis from idiopathic condylar resorption is crucial for effective management.
  • Comprehensive documentation of rare TMJ pathologies is essential for clinical advancement.

Observation:

  • The study documents clinical and radiographic findings in a patient with unilateral aggressive condylar resorption.
  • Conventional and advanced imaging revealed characteristic features of the condition.
  • Histopathologic examination provided definitive diagnostic information.

Findings:

  • The patient was diagnosed with osteoarthritis of the temporomandibular joint.
  • Aggressive condylar resorption was the primary manifestation.
  • Differential diagnosis considered idiopathic condylar resorption and other pathologies.

Implications:

  • This case underscores the importance of a systematic approach in diagnosing TMJ disorders.
  • Understanding the clinical and imaging features aids in early and accurate diagnosis.
  • Management strategies for osteoarthritis-induced condylar resorption can be refined based on these findings.