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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Related Experiment Video

Updated: May 14, 2026

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

From "magic bullets" to specific cancer immunotherapy.

Carsten Riether1, Christian Schürch, Adrian F Ochsenbein

  • 1Tumor Immunology, Department of Clinical Research, University of Bern, Switzerland.

Swiss Medical Weekly
|January 26, 2013
PubMed
Summary
This summary is machine-generated.

Immunotherapy shows promise in treating cancer by harnessing the immune system. Recent advances, including monoclonal antibodies, are improving patient survival and may soon target resistant cancer stem cells.

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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
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Published on: February 24, 2023

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Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle

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Area of Science:

  • Oncology
  • Immunology
  • Cancer Research

Background:

  • Immunotherapy aims to eliminate cancer cells with minimal side effects by leveraging the immune system's specificity.
  • Despite decades of research, particularly in malignant melanoma, clinical outcomes have often been disappointing, with limited success in inducing significant clinical responses.
  • Recent advancements in molecular techniques and a deeper understanding of tumor immunosurveillance have paved the way for novel immunotherapy strategies.

Purpose of the Study:

  • To review the current status of cancer immunotherapy in clinical practice.
  • To discuss emerging immunotherapy approaches and their potential impact on cancer treatment.
  • To explore the future prospects of immunotherapy, including targeting cancer stem cells.

Main Methods:

  • Review of current clinical immunotherapy practices.
  • Analysis of recent molecular discoveries and their application in novel immunotherapy strategies.
  • Examination of data from phase III clinical trials evaluating immunotherapy efficacy.

Main Results:

  • Immunotherapy has demonstrated the ability to prolong survival in patients with metastatic melanoma and prostate cancer.
  • Rapid developments in the field include the testing of various immune-activating molecules, primarily monoclonal antibodies, in clinical trials.
  • Early evidence suggests that novel immunotherapy approaches may hold the key to targeting treatment-resistant cancer stem cells.

Conclusions:

  • Immunotherapy is rapidly evolving and poised to significantly alter cancer treatment paradigms.
  • The ultimate goal of curing cancer through immunotherapy remains challenged by the resistance of cancer stem cells.
  • Future research and development in immunotherapy hold the potential to specifically target and eliminate cancer stem cells, offering new hope for a complete cure.