Related Experiment Video

Updated: May 14, 2026

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43
06:06

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43

Published on: September 11, 2020

Serotypeº1 [corrected] childhood invasive pneumococcal disease has unique characteristics compared to disease caused

Inbal Fuchs1, Ron Dagan, Noga Givon-Lavi

  • 1Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, Israel.

The Pediatric Infectious Disease Journal
|January 26, 2013
PubMed

Insights

Serotype 1 invasive pneumococcal disease (IPD) is more common in older, Bedouin children and linked to specific conditions like bacteremic pneumonia. This contrasts with other common serotypes (MCS) in IPD cases.

Area of Science:

  • Pediatric Infectious Diseases
  • Bacteriology
  • Epidemiology

Background:

  • Invasive pneumococcal disease (IPD) is a significant global health concern.
  • Distinguishing between different pneumococcal serotypes is crucial for understanding disease patterns and developing targeted interventions.

Purpose of the Study:

  • To differentiate serotype 1 (SP1) IPD from IPD caused by other common serotypes (MCS) based on demographic, clinical, and laboratory features.
  • To identify unique characteristics associated with SP1-IPD.

Main Methods:

  • Retrospective analysis of all pediatric IPD cases (<18 years) at Soroka University Medical Center (2000-2009).
  • Comparison of SP1-IPD episodes with MCS-IPD episodes, adjusting for age and ethnicity.

Main Results:

  • SP1-IPD cases were older and more prevalent in Bedouin children compared to MCS-IPD.
  • SP1 was less common in children with underlying diseases but more frequently associated with bacteremic pneumonia and primary peritonitis.
  • No significant differences were observed in hospitalization or mortality rates between SP1-IPD and MCS-IPD.

Conclusions:

  • Serotype 1 IPD exhibits distinct demographic and clinical associations compared to other common serotypes.
  • SP1-IPD is more prevalent in older and Bedouin children and linked to specific severe presentations like bacteremic pneumonia.
Abstract

More Related Videos

Capsular Serotyping of Streptococcus pneumoniae Using the Quellung Reaction04:25

Capsular Serotyping of Streptococcus pneumoniae Using the Quellung Reaction

Published on: February 24, 2014

Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination09:11

Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination

Published on: September 25, 2014

Related Concept Videos

Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...