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Updated: May 14, 2026
Transplantation into the Anterior Chamber of the Eye for Longitudinal, Non-invasive In vivo Imaging with Single-cell Resolution in Real-time
Published on: March 10, 2013
Study of the ophthalmic system of babies delivered to transplant recipients
Bozena Kociszewska-Najman1, Bronislawa Pietrzak, Joanna Moneta-Wielgos
1Division of Neonatology, 1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland.
Insights
Children born to mothers who underwent liver or renal transplantation showed no increased risk of ophthalmologic disorders. Immunosuppressive therapy during pregnancy did not negatively impact ocular development in neonates.
Area of Science:
- Ophthalmology
- Neonatology
- Transplantation Medicine
Background:
- Maternal organ transplantation (liver/renal) may influence neonatal outcomes.
- Assessing ophthalmologic health in children born after transplantation is crucial.
Purpose of the Study:
- To analyze ophthalmologic disorders in children born to mothers post-liver transplantation (LTx) or renal transplantation (RTx).
- To evaluate neonatal parameters in relation to maternal transplantation history.
Main Methods:
- Ophthalmologic examinations were conducted on 37 children post-LTx, 35 post-RTx, and 66 controls.
- Retrospective analysis of neonatal and maternal parameters was performed.
Main Results:
- No statistically significant differences in ophthalmologic disorders were found between LTx, RTx, and control groups.
- Preterm delivery rates were higher in the RTx group (68.8%) compared to LTx (43.2%).
- Minor ophthalmologic issues like convergence insufficiency and hyperopia were observed but not significantly different across groups.
Conclusions:
- Maternal immunosuppressive treatment during pregnancy did not adversely affect ocular development in offspring.
- Children born after LTx or RTx generally exhibit good ocular health.
Background:
The aim of the study was the analysis of ophthalmologic disorders in children born to mothers after liver transplantation (LTx) or renal transplantation (RTx) with the assessment of certain neonatal parameters.
Methods:
In the period between 01 January 2010 and 30 June 2012, ophthalmologic examinations were performed in 37 children born to mothers after LTx and 35 children after RTx, as well as 66 children from a control group, born at the 1st Department of Obstetrics and Gynecology, Medical University of Warsaw, from 01 January 2001 to 30 June 2012. Certain parameters of the neonatal period of the child and the mother were retrospectively analyzed.
Results:
Good first-minute states of neonates were observed in 89.2% LTx and 97.1% RTx but in the fifth minute in more than 97% of neonates in both groups. In the LTx and RTx groups, the percentage of preterm deliveries was 48.8% (68.8% in the RTx and 43.2% in the LTx; P=0.0306). There were differences in the immunosuppressant drug therapy in monotherapy as well as two to three drug combinations between the two groups. Children from the LTx, RTx, and control groups had no ophthalmologic disorders in more than 80%. In the LTx and RTx groups, there were convergence insufficiency (6 of 72), strabismus (2 of 72), and hyperopia (2 of 72). The differences in disorders between LTx and RTx groups, as well as LTx+RTx and control groups, were not statistically significant (P=1.00 vs. 0.6206). Retinopathy of prematurity was diagnosed in only two neonates in the RTx group.
Conclusions:
Immunosuppressive treatment during pregnancy, regardless of kind, did not affect the ocular organ's development.
