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Cell survival and apoptosis signaling as therapeutic target for cancer: marine bioactive compounds

Senthilkumar Kalimuthu1, Kim Se-Kwon

  • 1Marine Bioprocess Research Center, Department of Chemistry, Pukyong National University, Busan 608-737, Korea. sknkim@pknu.ac.kr.

International Journal of Molecular Sciences
|January 26, 2013
PubMed

Insights

Cancer cells evade apoptosis, promoting survival and proliferation. Targeting apoptosis and survival pathways, potentially with marine compounds, offers new therapeutic strategies for cancer treatment.

Area of Science:

  • Molecular Biology
  • Oncology
  • Pharmacology

Background:

  • Apoptosis, or programmed cell death, is crucial for homeostasis and is dysregulated in cancer.
  • Cancer cells often inhibit apoptosis and activate cell survival factors (e.g., AKT) for continuous proliferation.
  • Understanding the interplay between apoptosis and cell survival signaling is key for developing effective cancer therapies.

Purpose of the Study:

  • To review the signaling pathways of apoptosis and cell survival in cancer.
  • To explore the potential of targeting these pathways for cancer treatment.
  • To discuss the role of marine bioactive compounds as potential therapeutic agents.

Main Methods:

  • Literature review of apoptosis and cell survival mechanisms.
  • Analysis of signaling pathways involved in cancer cell proliferation and death.
  • Exploration of existing and potential therapeutic strategies.

Main Results:

  • Inhibition of apoptosis and activation of survival factors promote cancer cell proliferation.
  • Anticancer agents can induce apoptosis and inhibit survival, correlating with tumor response.
  • Different types of cell death (apoptosis, necrosis, senescence) are induced by DNA damage magnitude.

Conclusions:

  • Targeting apoptosis and cell survival pathways is a promising anticancer strategy.
  • Marine bioactive compounds may offer novel therapeutic avenues for cancer eradication.
  • Exploiting alternative cell death mechanisms could lead to new cancer control strategies.

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