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Published on: June 5, 2012
Pseudomonas and Aspergillus interaction in malignant external otitis: risk of treatment failure
1ENT-Ear Surgery Unit, Az. Ospedaliera, via Giustiniani 2, Padua, Italy. roberto.bovo@sanita.padova.it
Abstract:
Malignant external otitis (MEO) is a rare infection of the temporal bone primarily affecting elderly patients and diabetics or immunocompromised individuals, which may have dismal prognosis if treatment is not prompt and adequate. Almost 95% of MEO cases reported in the literature are attributed to Pseudomonas aeruginosa, and this pathogen is isolated from aural drainage in > 90% of cases. However, in recent years fungal and polymicrobial temporal bone infections have been reported with increasing frequency. The aim of this paper is to discuss a possible pitfall in MEO treatment using an unusual clinical case. In this patient, bacteriological data positive for Pseudomonas delayed correct diagnosis of Aspergillus infection, which was obtained after surgical debridement and biopsy of the infra-temporal space.
Insights
Malignant external otitis (MEO) is a rare temporal bone infection. Prompt diagnosis is crucial, as Pseudomonas aeruginosa is often implicated, but fungal infections like Aspergillus can be missed, delaying critical treatment.
Area of Science:
- Infectious Diseases
- Otolaryngology
- Mycology
Background:
- Malignant external otitis (MEO) is a severe temporal bone infection.
- Predominantly affects elderly, diabetic, or immunocompromised individuals.
- Pseudomonas aeruginosa is the most common pathogen (>90% of cases).
Observation:
- Recent increase in fungal and polymicrobial MEO cases.
- A clinical case highlights a diagnostic pitfall.
- Initial positive Pseudomonas findings delayed Aspergillus diagnosis.
Findings:
- Delayed diagnosis of Aspergillus infection occurred.
- Surgical debridement and biopsy were essential for correct diagnosis.
- Bacteriological data can sometimes be misleading in MEO.
Implications:
- Highlights the importance of considering non-bacterial pathogens in MEO.
- Emphasizes the need for comprehensive diagnostic approaches beyond routine cultures.
- Suggests potential for improved MEO treatment strategies by avoiding diagnostic delays.
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