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Related Experiment Video

Updated: May 14, 2026

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing (ChIP-seq)

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing (ChIP-seq)

Published on: April 19, 2013

Variants in the 15q24/25 locus associate with lung function decline in active smokers.

Firdaus A A Mohamed Hoesein¹, Els Wauters, Wim Janssens

¹Division of Heart and Lungs, Department of Respiratory Medicine, University Medical Center, Utrecht, The Netherlands. fmohamedhoesein@gmail.com

|January 26, 2013

Summary

Genetic variants in nicotinic acetylcholine receptor subunit genes (nAChRs) accelerate lung function decline in smokers. These variants also increase the risk of severe chronic obstructive pulmonary disease (COPD) and lung transplantation.

Related Experiment Videos

Last Updated: May 14, 2026

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing (ChIP-seq)

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing (ChIP-seq)

Published on: April 19, 2013

Area of Science:

Genetics
Pulmonology
Pharmacogenomics

Background:

Genetic variations in nicotinic acetylcholine receptor subunit genes (nAChRs) are linked to lung function and chronic obstructive pulmonary disease (COPD).
The impact of these variants on the rate of lung function decline remains largely unknown.

Purpose of the Study:

To investigate the association between nAChR susceptibility variants and lung function decline.
To examine the relationship between these variants and COPD severity.

Main Methods:

Genotyping of rs1051730 and rs8034191 variants in two independent cohorts of heavy smokers (COPACETIC and LEUVEN).
Assessment of lung function decline over a median follow-up of 3 years.
Analysis of COPD severity, including GOLD stages and need for lung transplantation.

Main Results:

Current smokers homozygous for the rs1051730 A-allele or rs8034191 G-allele showed significantly greater FEV1/FVC decline.
Carriers of these risk alleles had a two-fold increased risk of severe COPD (GOLD IV).
Risk alleles conferred a five- and four-fold increased risk for lung transplantation due to end-stage COPD.

Conclusions:

nAChR variants are associated with accelerated lung function decline in European smokers.
These genetic variants are linked to clinically significant COPD severity and adverse outcomes.