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Updated: May 14, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

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Skin involvement in primary systemic amyloidosis.

Susheel Kumar¹, Rimi Som Sengupta, Nandita Kakkar

¹Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Mediterranean Journal of Hematology and Infectious Diseases

|January 26, 2013

Summary

Primary systemic amyloidosis, a rare condition, can cause unusual skin manifestations. This case highlights papular eruptions on the eyelids and chest, confirmed by biopsy, offering insights into this uncommon presentation.

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Rapid Generation of Amyloid from Native Proteins In vitro

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Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

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Rapid Generation of Amyloid from Native Proteins In vitro

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

Area of Science:

Hematology
Dermatology
Pathology

Background:

Primary systemic amyloidosis is a rare multisystem disorder.
Commonly affects kidneys, heart, nerves, and liver.
Typical skin lesions include bruising (petechiae, purpura, ecchymoses) due to amyloid infiltration of blood vessels.

Observation:

This report details a unique case of primary systemic amyloidosis.
The patient presented with multiple, non-pruritic papular lesions on the lower eyelids and chest wall.
These papular eruptions represent an uncommon cutaneous manifestation of the disease.

Findings:

Diagnosis was confirmed via skin biopsy of the papular lesions.
Congo red staining of the biopsy specimen revealed amyloid deposits.
The findings underscore the diverse potential skin involvements in systemic amyloidosis.

Implications:

Highlights the importance of considering amyloidosis in patients with unusual skin findings.
Suggests papular eruptions may be an under-recognized sign of primary systemic amyloidosis.
Emphasizes the diagnostic value of skin biopsy and specific staining techniques.