Related Experiment Video

Updated: May 14, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

[Oncolytic viruses in the therapy of gliomas]

N V Gubanova, A S Gaĭtan, I A Razumov

    Molekuliarnaia Biologiia
    |January 29, 2013
    PubMed

    Insights

    Glioblastoma remains difficult to treat due to invasive nature and stem cell resistance. Oncolytic viruses show promise for treating malignant gliomas, with ongoing research to improve their effectiveness.

    Area of Science:

    • Neuro-oncology
    • Virology
    • Cancer Therapy

    Context:

    • Malignant glioblastoma presents significant therapeutic challenges due to its invasive nature and location within critical brain areas.
    • Current treatments like surgery, radiation, and chemotherapy are limited by tumor recurrence and resistance from glioma stem cells.
    • Advances in genetic engineering have enabled the development of oncolytic viruses with targeted cancer-fighting capabilities.

    Purpose:

    • To review the progress and clinical trial outcomes of oncolytic viruses for malignant glioma treatment.
    • To discuss the potential and limitations of current oncolytic virus strains in virotherapy.
    • To explore future directions and improvements for enhancing oncolytic virotherapy efficacy.

    Summary:

    • Recombinant oncolytic viruses demonstrate oncolytic activity against glial tumors and have shown safety in Phase I clinical trials.
    • Despite promising safety profiles, existing oncolytic virus strains require further optimization to achieve sufficient therapeutic efficacy for glioblastoma.
    • The review highlights successful oncolytic virus variants that have entered clinical trials and discusses prospects for novel virotherapy approaches.

    Impact:

    • Oncolytic virus therapy offers a novel strategy for targeting glioblastoma, potentially overcoming resistance to conventional treatments.
    • Further development of oncolytic viruses could lead to more effective treatments for malignant gliomas, improving patient outcomes.
    • This research paves the way for enhanced virotherapy strategies against challenging brain tumors.

    More Related Videos

    Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts11:15

    Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

    Published on: September 1, 2018

    Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care12:55

    Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

    Published on: February 16, 2015

    Related Concept Videos

    Cancer Therapies02:49

    Cancer Therapies

    Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
    However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
    Tumor Immunotherapy01:27

    Tumor Immunotherapy

    Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
    Treatment Resistent Cancers02:56

    Treatment Resistent Cancers

    Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
    Treatment Resistant Cancers02:56

    Treatment Resistant Cancers

    Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
    Targeted Cancer Therapies02:57

    Targeted Cancer Therapies

    The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
    There are several types of targeted therapies against specific...
    Targeted Cancer Therapies02:57

    Targeted Cancer Therapies

    The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
    There are several types of targeted therapies against specific...