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VARIANT: a store and retrieval system for human haemoglobin variants.

M F Macchiato1, A Tramontano

  • 1Dipartimento di Scienze Fisiche, Naples, Italy.

Computer Methods and Programs in Biomedicine
|February 1, 1990
PubMed
Summary

VARIANT is a computer system for tracking human haemoglobin variants. This tool aids in studying protein evolution by cataloging amino acid replacements in homologous proteins.

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Area of Science:

  • Biochemistry
  • Bioinformatics
  • Computational Biology

Background:

  • Human haemoglobin variants result from amino acid replacements.
  • Understanding these variants is crucial for genetic and evolutionary studies.
  • Existing methods for tracking variants can be cumbersome.

Purpose of the Study:

  • To present VARIANT, a novel computer system for managing haemoglobin variant data.
  • To provide a user-friendly and expandable tool for researchers.
  • To facilitate evolutionary studies through comprehensive data management.

Main Methods:

  • Development of a FORTRAN 77 computer system named VARIANT.
  • Implementation of a multicriterion basis for storing and retrieving amino acid replacements.

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  • Design for transportability and user-friendliness.
  • Capability for expansion to include homologous protein families.

    • Main Results:

    • VARIANT allows efficient storage and retrieval of human haemoglobin amino acid replacements.
    • The system is transportable and user-friendly.
    • VARIANT can be expanded to create databases for homologous protein families.
    • The system serves as an efficient tool for evolutionary studies.

    Conclusions:

    • VARIANT offers a robust solution for managing haemoglobin variant data.
    • The system's design promotes ease of use and adaptability.
    • VARIANT is a valuable asset for advancing research in protein evolution and human genetics.