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Updated: May 14, 2026
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Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
Published on: July 15, 2015
Perioperative intravascular volume replacement and kidney insufficiency
Zaccaria Ricci1, Stefano Romagnoli, Claudio Ronco
1Department of Cardiology and Cardiac Surgery, Pediatric Cardiac Intensive Care Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. z.ricci@libero.it
Best Practice & Research. Clinical Anaesthesiology
|January 29, 2013
Summary
Perioperative acute kidney injury (AKI) is rising due to complex surgeries. Fluid replacement strategies significantly impact kidney function, highlighting the need for careful fluid management to prevent renal dysfunction.
Area of Science:
- Nephrology
- Anesthesiology
- Critical Care Medicine
Background:
- Perioperative acute kidney injury (AKI) incidence is increasing, linked to more complex surgeries and sicker patients.
- AKI has a multifactorial etiology, including comorbidities, surgical factors, and nephrotoxic exposures.
- Fluid administration during surgery is a critical factor potentially influencing kidney injury.
Purpose of the Study:
- To review the association between fluid replacement strategies and perioperative acute kidney injury.
- To analyze the impact of fluid quality and quantity on renal dysfunction in the perioperative period.
Main Methods:
- Literature review focusing on perioperative fluid management and AKI.
- Analysis of studies examining crystalloids, colloids, and hemoderivatives in relation to kidney injury.
Main Results:
- Fluid choice and administration strategies are implicated in perioperative AKI.
- Both the type and volume of fluids administered can contribute to renal dysfunction.
- Further research is needed to elucidate optimal fluid management protocols.
Conclusions:
- Fluid replacement is a significant modifiable factor in preventing perioperative AKI.
- Careful consideration of fluid type and quantity is essential for renal protection during surgery.
- Optimizing perioperative fluid management may reduce the incidence of AKI.
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