Related Experiment Video
Updated: May 14, 2026

Assay Development for High-Throughput Drug Screening Against Mycobacteria
Published on: October 25, 2024
Synthesis and biological evaluation of propargyl acetate derivatives as anti-mycobacterial agents
Parisa Azerang1, Ali Hossein Rezayan, Soroush Sardari
1Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute, Tehran, Iran 13164. ssardari@hotmail.com.
Background:
The emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has intensified efforts to discover novel drugs for tuberculosis (TB) treatment. Targeting the persistent state of Mtb, a condition in which Mtb is resistant to conventional drug therapies, is of particular interest.
Methods:
This study is focused on propargyl acetate derivatives. Eight molecules were designed based on propargyl alcohols and different acid anhydrides.
Results:
All the synthesized compounds and commercially available ones were evaluated for anti-tuberculosis activity.
Conclusions:
Inhibitors against Mtb have been identified and characterized for further development into potential novel anti-tubercular drugs.
Related Concept Videos
Antifungal Agents
Inhibitors of Gram-positive Cell Wall Synthesis
Antimicrobial Effectiveness
