Related Experiment Video
Updated: May 14, 2026
05:44
Rodent Inferior Vena Cava Venoplasty Balloon Model
Published on: May 24, 2024
Deep venous thrombosis and atypical antipsychotics: three cases report
Fatemeh Sheikhmoonesi1, Seyyedeh Fatemeh Bahari Saravi
1Psychiatry and Behavioral Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran. fmoonesi@mazums.ac.ir.
Summary
Deep venous thrombosis (DVT), a serious condition, can occur in psychiatric patients using atypical antipsychotics like olanzapine and risperidone. This risk exists even without prior DVT history or other common risk factors.
Area of Science:
- Psychiatry
- Pharmacology
- Vascular Medicine
Background:
- Deep venous thrombosis (DVT) is a potentially life-threatening condition often overlooked in psychiatric settings.
- Atypical antipsychotics are commonly prescribed for various psychiatric disorders.
Purpose of the Study:
- To present three cases of deep venous thrombosis (DVT) that developed after initiating treatment with olanzapine and risperidone.
- To highlight the potential association between atypical antipsychotic use and DVT in psychiatric patients.
Main Methods:
- Case study approach.
- Review of hospital records for three patients diagnosed with DVT.
- Analysis of patient history, including physical health, BMI, and personal/familial history of DVT.
Main Results:
- Three patients developed DVT after starting treatment with risperidone or olanzapine.
- Patients were in good general physical health with no prior history of DVT.
- Patients had a normal Body Mass Index (BMI < 25).
Conclusions:
- A risk of DVT exists in patients treated with atypical antipsychotics, even in the absence of pre-existing risk factors.
- Clinicians should be vigilant for DVT in psychiatric patients on atypical antipsychotics.
- Further research is warranted to elucidate the mechanisms and prevalence of DVT associated with these medications.
Related Concept Videos
01:29Venous Thrombosis III: Interprofessional Care
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
01:21Antipsychotic Drugs: Typical and Atypical Agents
Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
01:30Venous Thrombosis I: Introduction
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
01:30Venous Thrombosis IV: Nursing Management
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
01:28Psychosis and Antipsychotic Drugs: Overview
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic symptoms in all...