Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbial Corrosion01:24

Microbial Corrosion

Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...
Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
Drug Toxicity: Dose-Dependent Reactions01:24

Drug Toxicity: Dose-Dependent Reactions

Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
Types of Toxins01:36

Types of Toxins

Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Toxic Reactions: Overview01:26

Toxic Reactions: Overview

When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unrecognized Temporomandibular Joint Dislocation After Intubation, A Case Report.

The Journal of emergency medicine·2026
Same author

Practice changing articles: Defibrillation in refractory ventricular fibrillation following out-of-hospital cardiac arrest.

The American journal of emergency medicine·2026
Same author

Threat of Melee-related Terrorist Attacks: A Retrospective Analysis of Patterns, Mortality, and Public Health Impact.

Disaster medicine and public health preparedness·2026
Same author

Practice changing articles: Multidose ondansetron after emergency visits in children with gastroenteritis.

The American journal of emergency medicine·2026
Same author

The authors' responses: "Reader comment regarding prophylactic antibiotics for immunosuppressed individuals with anterior nasal packing: A propensity score matching study".

The American journal of emergency medicine·2026
Same author

Routine chest X-ray in atraumatic chest pain with normal vital signs: A propensity-matched TriNetX analysis.

The American journal of emergency medicine·2026
Same journal

Therapeutic targeting of COX-2 in head and neck cancer: Mechanistic and clinical perspectives.

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences·2026
Same journal

Chitosan-carboxymethyl tara gum polyelectrolyte complex matrix tablets for sustained gastrointestinal drug dissolution using paracetamol as a model drug.

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences·2026
Same journal

Wistar rat model experiments for increasing intraocular pressure: a systematic review.

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences·2026
Same journal

Bridging solubility, stability, and translation: advances in carbon nanotube-based drug delivery systems.

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences·2026
Same journal

Aprepitant's neuroprotective effects on methylphenidate-induced biochemical/mitochondrial dysfunction, neuroinflammation, and mood-related behavior alterations.

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences·2026
Same journal

Cephaeline promotes ferroptosis in breast cancer via p53/SLC7A11/GPX4 axis.

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences·2026
See all related articles

Related Experiment Video

Updated: May 14, 2026

Testing of Nanoparticle Release from a Composite Containing Nanomaterial Using a Chamber System
04:55

Testing of Nanoparticle Release from a Composite Containing Nanomaterial Using a Chamber System

Published on: November 22, 2016

Current opinion on nanotoxicology.

Ali Pourmand1, Mohammad Abdollahi

  • 1Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, 1417614411, Iran. Mohammad.Abdollahi@UToronto.Ca.

Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
|January 29, 2013
PubMed
Summary
This summary is machine-generated.

Nanotechnology offers advancements but poses safety challenges. Addressing nanotoxicology requires identifying toxic materials, categorizing nanoparticles, and understanding biological interactions for safe healthcare integration.

More Related Videos

In Situ Detection and Single Cell Quantification of Metal Oxide Nanoparticles Using Nuclear Microprobe Analysis
14:53

In Situ Detection and Single Cell Quantification of Metal Oxide Nanoparticles Using Nuclear Microprobe Analysis

Published on: February 3, 2018

Experimental Protocol to Investigate Particle Aerosolization of a Product Under Abrasion and Under Environmental Weathering
07:47

Experimental Protocol to Investigate Particle Aerosolization of a Product Under Abrasion and Under Environmental Weathering

Published on: September 16, 2016

Related Experiment Videos

Last Updated: May 14, 2026

Testing of Nanoparticle Release from a Composite Containing Nanomaterial Using a Chamber System
04:55

Testing of Nanoparticle Release from a Composite Containing Nanomaterial Using a Chamber System

Published on: November 22, 2016

In Situ Detection and Single Cell Quantification of Metal Oxide Nanoparticles Using Nuclear Microprobe Analysis
14:53

In Situ Detection and Single Cell Quantification of Metal Oxide Nanoparticles Using Nuclear Microprobe Analysis

Published on: February 3, 2018

Experimental Protocol to Investigate Particle Aerosolization of a Product Under Abrasion and Under Environmental Weathering
07:47

Experimental Protocol to Investigate Particle Aerosolization of a Product Under Abrasion and Under Environmental Weathering

Published on: September 16, 2016

Area of Science:

  • Nanotechnology
  • Nanotoxicology
  • Biomedical Engineering

Background:

  • Nanotechnology is rapidly advancing, increasing its presence in science and public awareness.
  • Despite growth, potential safety hazards and limitations of nanotechnology in industries are still under investigation.
  • A meta-perspective analysis of global nanotechnology use is hindered by insufficient data.

Purpose of the Study:

  • To highlight the critical challenges in nanotoxicology for safe nanotechnology integration.
  • To emphasize the need for a structured approach to understanding and managing nanoparticle risks.
  • To advocate for mechanism-driven research in assessing nanoparticle roles in healthcare.

Main Methods:

  • Identification of potentially toxic nanomaterials.
  • Development of a classification system for nanoparticle materials.
  • Investigation of biological interactions of nanoparticles.

Main Results:

  • Three key challenges in nanotoxicology are defined: material identification, categorization, and understanding biological interactions.
  • The necessity of developing standardized research methods for nanoscale data collection is underscored.
  • The importance of interdisciplinary collaboration among experts is highlighted for integrating nanotoxicity assessment into medicine.

Conclusions:

  • Addressing nanotoxicology requires a multi-faceted approach focusing on material safety, classification, and biological impact.
  • Standardized research protocols are essential for gathering reliable nanoscale data.
  • Interdisciplinary collaboration and mechanism-driven research are crucial for the safe application of nanotechnology in healthcare.