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Updated: May 14, 2026

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

Inducing γ oscillations and precise spike synchrony by operant conditioning via brain-machine interface.

Ben Engelhard¹, Nofar Ozeri, Zvi Israel

¹Department of Medical Neurobiology, Institute of Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Hadassah University Hospital, Jerusalem 91120, Israel. ben.engelhard@mail.huji.ac.il

|January 29, 2013

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Monkeys learned to control low-gamma brain waves using a brain-machine interface (BMI), enhancing neuronal synchrony and improving task performance. This demonstrates volitional control over neural activity for potential clinical applications.

Area of Science:

Neuroscience
Computational Neuroscience
Brain-Machine Interfaces

Background:

Low-gamma oscillations (30-50 Hz) are linked to neuronal synchrony, cognition, and behavior.
Abnormal low-gamma activity is observed in various brain disorders, suggesting impaired neural synchronization.

Purpose of the Study:

To investigate the relationship between volitional control of low-gamma oscillations, neuronal synchrony, and behavioral outcomes.
To explore the potential of brain-machine interfaces (BMIs) for modulating neural activity and understanding brain function.

Main Methods:

A brain-machine interface (BMI) was used to train non-human primates to increase low-gamma power in the motor cortex.
The study monitored neural activity, including local field potential (LFP) oscillations and spiking synchrony, during a cursor control task.

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Related Experiment Videos

Last Updated: May 14, 2026

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

Generation of Local CA1 γ Oscillations by Tetanic Stimulation

Generation of Local CA1 γ Oscillations by Tetanic Stimulation

Published on: August 14, 2015

Multichannel Extracellular Recording in Freely Moving Mice

Multichannel Extracellular Recording in Freely Moving Mice

Published on: May 26, 2023

Main Results:

Monkeys successfully learned to volitionally increase low-gamma power in targeted motor cortex sites.
This increase in gamma oscillations was associated with enhanced neuronal spiking synchrony and precise spatiotemporal patterns.
Improved control of the BMI task and reward acquisition were observed.

Conclusions:

Volitional control of low-gamma oscillations directly influences neuronal synchrony and behavioral performance.
This research provides a novel approach for studying neural processing and has implications for clinical applications of BMIs.