Related Experiment Video
Updated: May 14, 2026

Following the Dynamics of Structural Variants in Experimentally Evolved Populations
Published on: February 3, 2023
Models of compensatory molecular evolution: effects of back mutation
Motoshi Ichinose1, Masaru Iizuka, Junko Kusumi
1Department of Contemporary Liberal Arts, Junior College, Chikushi Jogakuen University, 2-12-1 Ishizaka, Dazaifu 818-0192, Japan.
Abstract:
Compensatory mutations are individually deleterious but appropriate combinations of mutants are harmless. For several models of compensatory molecular evolution, we consider the effects of back mutation. It is shown that the effects of back mutation on the rate of compensatory molecular evolution are weak. Further we estimate the values of selection parameter of deleterious single mutants for the models of compensatory molecular evolution both with and without back mutation using sequence data of folded RNA molecules and compare them with the previous results.
Related Concept Videos
Mismatch Repair
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Mismatch Repair
Mutations in Microorganisms
Spontaneous and Induced Mutations
Mutation, Gene Flow, and Genetic Drift
Gene Evolution - Fast or Slow?
In contrast, regions which code...

