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Tamoxifen-loaded lecithin organogel (LO) for topical application: Development, optimization and characterization
Amit Bhatia1, Bhupinder Singh, Kaisar Raza
1School of Pharmaceutical Sciences, Faculty of Applied Medical Sciences, Lovely Professional University, Phagwara, Panjab, India.
Lecithin organogels (LOs) were optimized for topical delivery. The study found that LO attributes significantly depend on components like phospholipids and Poloxamer™, leading to stable, biocompatible formulations.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Lecithin organogels (LOs) are versatile semi-solid systems.
- Their development requires understanding material interactions and formulation optimization.
Purpose of the Study:
- To systematically optimize lecithin organogel composition.
- To characterize the optimized formulations for topical delivery applications.
Main Methods:
- Screening of gelators, organic, and aqueous phases.
- D-optimal mixture design for composition optimization.
- Characterization of rheology, stability, and physical properties.
Main Results:
- LO attributes showed high dependence on phospholipid, Poloxamer™, auxiliary gelators, and solvent.
- Optimized formulations demonstrated excellent stability, applicability, and biocompatibility.
- Response surface plots and overlay plots guided composition optimization.
Conclusions:
- Systematic optimization using mixture design is effective for LO development.
- Optimized LOs are suitable for safe and effective topical drug delivery.
- Findings can guide the development of LO systems for various drugs.
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