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Updated: May 14, 2026

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

[Real-time three-dimensional echocardiographic assessment of left ventricular diastolic dyssynchrony and dysfunction

Bei Zhao1, Juan Li, Wei-Hong Zhu

  • 1Department of Cardiology, General Hospital of PLA, Beijing, China. rubyzhao1212@126.com

Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University
|January 29, 2013
PubMed

Insights

Real-time 3D echocardiography detects early diastolic dysfunction in hypertrophic cardiomyopathy (HCM) patients. Early diastolic dyssynchrony is more pronounced and correlates better with diastolic dysfunction severity than late diastolic changes.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Hypertrophic cardiomyopathy (HCM) is a primary genetic heart muscle disease.
  • Diastolic dysfunction is a key feature of HCM, impacting left ventricular (LV) filling.
  • Early detection of diastolic dysfunction is crucial for managing HCM patients.

Purpose of the Study:

  • To evaluate left ventricular (LV) regional diastolic function in hypertrophic cardiomyopathy (HCM) patients.
  • To utilize single-beat real-time three-dimensional echocardiography (RT-3DE) for assessing diastolic function.
  • To identify specific echocardiographic parameters indicative of diastolic dysfunction in HCM.

Main Methods:

  • Sixty-nine HCM patients (LV ejection fraction ≥45%) and 50 controls underwent 2D and RT-3DE.
  • RT-3DE analyzed end-diastolic sphericity index (EDSI) and diastolic dyssynchrony index (DDI).
  • Parameters included dispersion end diastole (DISPED) in early and late diastole; patients grouped by diastolic dysfunction severity.

Main Results:

  • Diastolic dyssynchrony index (DDI) and dispersion end diastole (DISPED) increased with diastolic dysfunction severity.
  • In severe dysfunction, late diastolic parameters (DDI-late, DISPED-late) were abnormal (P<0.0001).
  • Early diastolic parameters (DDI-early, DISPED-early) increased in mild and moderate dysfunction (P<0.0001).

Conclusions:

  • Early diastolic dyssynchrony is more evident than late diastolic dyssynchrony in HCM.
  • Early diastolic dyssynchrony correlates more strongly with the severity of diastolic dysfunction.
  • Single-beat RT-3DE can detect these preclinical diastolic abnormalities in HCM.
Abstract

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