Related Experiment Video

Updated: May 14, 2026

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay
09:03

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay

Published on: March 10, 2020

β-Arrestin-1 directly interacts with Gαs and regulates its function

Bo Li1, Congcong Wang, Zhaocai Zhou

  • 1State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, PR China.

FEBS Letters
|January 29, 2013
PubMed
Summary

This study reveals that beta-arrestin-1 directly interacts with G alpha(s) proteins, influencing their GTP binding and release. This finding uncovers a direct crosstalk between beta-arrestin and G protein signaling pathways.

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